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KMID : 0363220080460091257
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Korean Journal of Dermatology
2008 Volume.46 No. 9 p.1257 ~ p.1261
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A Case of Doxifluridine-Induced Multiple Atypical Moles on the Palm and Sole of a Patient Taking Immunosuppressive Agents
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Chung Woon-Kyung
Kang Seong-Min
Rhee Do-Young
Chang Sung-Eun
Lee Mi-Woo
Choi Jee-Ho
Moon Kee-Chan
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Abstract
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Doxifluridine is a pyrimidine derivative and is activated to 5-fluorouracil by pyrimidine phosphorylase. Multiple acral hyperpigmented macules have been reported in patients treated with systemic 5-fluorouracil or some of its prodrugs. However, there have been no reports of this adverse event being induced by doxifluridine. Herein we present a 42-year-old woman with multiple pigmented lesions on the palm and sole after chemotherapy with oral doxifluridine.
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KEYWORD
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5-Fluorouracil, Acral, Doxifluridine, Hyperpigmentation, Mole
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